To the Editor: Dr Ridker and colleagues1 assessed 35 blood-based biomarkers and traditional epidemiological risk factors to develop a new risk algorithm. It appears that no natriuretic peptide was tested for inclusion in this model. Natriuretic peptides have been shown to predict cardiovascular outcomes in multiple populations, including men and women in the general population and older adults.2- 5 It would be of interest to see how the addition of either B-type natriuretic peptide or amino-terminal pro-B-type natriuretic peptide might affect their proposed models for cardiovascular risk assessment in women.
Daniels LB, Ben-Yehuda O, Maisel AS. Algorithms for Assessing Cardiovascular Risk in Women. JAMA. 2007;298(2):175-178. doi:10.1001/jama.298.2.177-a