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July 18, 2007

Use of Corticosteroids to Prevent Atrial Fibrillation After Cardiac Surgery

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2007;298(3):283-284. doi:10.1001/jama.298.3.283-b

To the Editor: Dr Halonen and colleagues1 found that intravenous hydrocortisone significantly reduced the incidence of AF after cardiac surgery with cardiopulmonary bypass (adjusted hazard ratio, 0.54; 95% confidence interval, 0.35-0.83; P = .004; number needed to treat, 5.6). The statistical analysis accounted for established predictors of AF, such as age, sex, ejection fraction, type of operation, pulmonary disease, and coronary artery disease.

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