A number of genes are expressed at high levels only in the blood vessels that feed tumors, according to studies in mice and humans by investigators at the National Cancer Institute's facility in Frederick, Md (Seaman et al. Cancer Cell. 2007;11:539-554). The finding may be useful for advancing antiangiogenesis strategies, approaches that aim to disrupt the growing blood vessels that support tumor growth.
Current vascular-targeted therapies may damage normal growing blood vessels, but the identification of genes that are highly active specifically in vessels that supply tumors may help scientists develop therapies that primarily target vessels associated with cancer.
Hampton T. Tumor Blood Vessels. JAMA. 2007;298(4):394. doi:10.1001/jama.298.4.394-c