To the Editor: Based on their meta-analysis of antioxidant supplementation trials, Dr Bjelakovic and colleagues1 conclude that some of the intervention nutrients appeared to be associated with increased mortality. Particular aspects of their approach, analysis, and reported findings may have led to incomplete or biased determinations of the real effect of such nutrients in various populations.
Albanes D. Antioxidant Supplements and Mortality. JAMA. 2007;298(4):400-403. doi:10.1001/jama.298.4.400-a