Letters Section Editor: Robert M. Golub, MD, Senior Editor.
In Reply: Drs Bachman and Histon are conflating 2 distinct but important considerations. We are in agreement on the need for scientific work aimed at understanding the complex etiology of obesity and believe that this requires the formulation of a testable hypothesis that can lead to well-controlled experiments to try to falsify it. This was the aim of our Commentary: to describe a hypothesis that can account for a large amount of information from disparate fields, and that provides a novel and testable conceptualization of the causes of obesity.
Pascual-Leone A, Alonso-Alonso M. Obesity and the Right Brain—Reply. JAMA. 2007;298(7):738-739. doi:10.1001/jama.298.7.738-b