New research conducted in part by scientists at the National Institutes of Health suggests that a genetically diverse mouse model, referred to as “Diversity Outbred” mice, will help predict the range of biological responses that may occur within a population after different chemical exposures (French JE et al. Environ Health Perspect.doi:10.1289/ehp.1408202 [published online November 6, 2014]). Traditionally, isogenic mice are used to assess the effects of exposure; however, because of lack of genetic diversity, these models may not accurately predict the range of sensitivities to chemicals in humans.
Hampton T. Unique Mice May Help Reveal Human Response to Chemical Exposure. JAMA. 2014;312(24):2608. doi:10.1001/jama.2014.17033