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In Reply Dr Carmack’s claim is at odds with results of numerous observational studies, meta-analyses, and 3 randomized controlled trials of medical male circumcision in Kenya, South Africa, and Uganda.1- 3 The trials found relative risk ratios of HIV infection that were between 0.40 and 0.49 at 18 to 24 months following circumcision, or a reduction in the risk of HIV acquisition by 50% to 60%.
Thirumurthy H, Agot K. Voluntary Medical Male Circumcision in Kenya—Reply. JAMA. 2014;312(24):2687. doi:10.1001/jama.2014.15024