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Clinical Trials Update
December 24/31, 2014

No Difference in Weight Regain From Fast or Slow Diet

JAMA. 2014;312(24):2609. doi:10.1001/jama.2014.16824

Losing weight slowly and steadily, as recommended by dietary guidelines for treating obesity, provides no advantage in maintaining weight loss compared with very-low-calorie diets that shed pounds quickly.

An Australian trial randomly assigned 200 obese adults (body mass index, 30-45) to either a 12-week rapid weight loss (RWL) program with a very-low-calorie diet (450-800 kcal/d) or a 36-week gradual weight loss (GWL) program, which reduced energy intake by approximately 500 kcal/d (Purcell K et al. Lancet Diabetes Endocrinol.doi:10.1016/S2213-8587(14)70200-1 [published online October 16, 2014]).

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