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Lab Reports
September 12, 2007

HDL Boosters

JAMA. 2007;298(10):1152. doi:10.1001/jama.298.10.1152-a

Liver enzymes called proprotein convertases increase blood concentrations of “good” high-density lipoprotein (HDL) cholesterol in mice, according to studies led by researchers at the University of Pennsylvania School of Medicine, in Philadelphia (Jin W et al. Cell Metab. 2007;6[2]:129-136).

Specifically, the researchers found that treatments that partially block the activity of proprotein convertases decreased plasma HDL cholesterol levels. They also discovered that these enzymes act through another enzyme, endothelial lipase, which breaks down HDL cholesterol.

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