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Book and Media Reviews
September 19, 2007

HIV and the Pathogenesis of AIDS

Author Affiliations

Book and Media Reviews Section Editor: John L. Zeller, MD, PhD, Contributing Editor.

JAMA. 2007;298(11):1334-1340. doi:10.1001/jama.298.11.1334

Both the AIDS epidemic and research in human immunodeficiency virus (HIV)/AIDS have rapidly expanded during the quarter century since the discovery of this syndrome in 1981. In fact, the publication rate of HIV-related medical and scientific literature is too large to simultaneously keep adequately abreast of all aspects of the field. Jay A. Levy, MD, who has made seminal discoveries both in HIV virology and HIV immunology, recently published his third edition of HIV and the Pathogenesis of AIDS. This expanded version, which contains 56 additional pages and 1985 new references, brings into focus many of the important virological and immunological discoveries made during the 9-year interval since publication of the second edition. Unlike many other monographs on HIV/AIDS, the author handles both the virological and immunological aspects of this complex field with knowledge and apparent ease. The 15 updated chapters describe in detail many features of HIV, including its origin, structure, heterogeneity, cytopathic characteristics, interaction with and infection of susceptible host cells, and modes of transmission. From the perspective of the viral host, the book describes pathogenesis, HIV-specific humoral and cellular immunity, innate vs adaptive immunity, HIV-associated cancers, antiviral and immune-based therapies, and vaccine development.

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