[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.163.92.62. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Citations 0
The World in Medicine
September 19, 2007

Glaucoma Clues

JAMA. 2007;298(11):1268. doi:10.1001/jama.298.11.1268-a

Research by scientists in England and Italy suggest that amyloid beta protein, the major constituent of the brain plaques that are a hallmark of Alzheimer disease, might also be responsible for retinal cell death in patients with glaucoma (Guo L et al. Proc Natl Acad Sci U S A. 2007;104[33]:13444-13449).

Using a rat model of glaucoma, the researchers found that amyloid beta accumulates in dying retinal ganglion cells and that adding this protein to retinal cells in vivo induced cell death. They also found that giving the animals agents that inhibit the formation and accumulation of amyloid beta reduced death of retinal ganglion cells, especially when given in combination.

First Page Preview View Large
First page PDF preview
First page PDF preview
×