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Comment & Response
January 6, 2015

Risk Profile of Clinical Trial Participants

Author Affiliations
  • 1Cardiology Division, Massachusetts General Hospital, Boston
  • 2Cardiovascular Institute, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey

Copyright 2015 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA. 2015;313(1):93-94. doi:10.1001/jama.2014.15630

To the Editor In their research letter, Dr Udell and colleagues1 stated that clinical trial participants had a lower risk profile and a more favorable prognosis compared with the broader population included in the National Cardiovascular Data Registry (NCDR) Acute Coronary Treatment and Intervention Outcomes Network Registry–Get With The Guidelines.

It is likely that these differences would be more pronounced if clinical trial participants were compared with patients with myocardial infarction in the broader US population because participation in the NCDR is voluntary and includes participation by only 5% of US hospitals.1,2 In addition, the data would be put in better perspective if the age of the patients with myocardial infarction in the NCDR and the rates of diagnostic cardiac catheterization and percutaneous coronary intervention were compared with a more inclusive database such as the Nationwide Inpatient Sample.2

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