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In Reply Dr Kostis and colleagues suggest that patients with myocardial infarction who participate in clinical trials may demonstrate even more pronounced differences in presenting factors, hospital care, and outcomes compared with patients included in the US Healthcare Cost and Utilization Project Nationwide Inpatient Sample. Although such a comparison could potentially bolster our findings, we are not aware of data from the sample documenting clinical trial participation to allow for a valid comparison.1
Udell JA, Roe MT, Wiviott SD. Risk Profile of Clinical Trial Participants—Reply. JAMA. 2015;313(1):94-95. doi:10.1001/jama.2014.15633