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Comment & Response
January 6, 2015

Risk Profile of Clinical Trial Participants—Reply

Author Affiliations
  • 1Women’s College Hospital, University of Toronto, Toronto, Ontario, Canada
  • 2Duke Clinical Research Institute, Duke University, Durham, North Carolina
  • 3Cardiovascular Division, Brigham and Women’s Hospital, Boston, Massachusetts

Copyright 2015 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA. 2015;313(1):94-95. doi:10.1001/jama.2014.15633

In Reply Dr Kostis and colleagues suggest that patients with myocardial infarction who participate in clinical trials may demonstrate even more pronounced differences in presenting factors, hospital care, and outcomes compared with patients included in the US Healthcare Cost and Utilization Project Nationwide Inpatient Sample. Although such a comparison could potentially bolster our findings, we are not aware of data from the sample documenting clinical trial participation to allow for a valid comparison.1

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