In Reply Drs Platts-Mills and Jones have raised a potential concern with the search strategy used in our study on reanalyses of randomized clinical trial data, specifically with respect to our restriction to studies indexed as a clinical trial publication type in MEDLINE. We agree with them that a strategy with no restriction to clinical trials publication type would be more sensitive in detecting reanalyses.
However, performing such a search would yield a total of 112 330 citations (limited to March 9, 2014, as per our original search). Screening this number of citations would be a daunting task and may not be a valuable use of resources if the output of additional studies retrieved would be few in number compared with the studies retrieved in our original search.
Ebrahim S, Ioannidis JPA. Reanalyses of Trial Results—Reply. JAMA. 2015;313(1):93. doi:10.1001/jama.2014.15644