JAMA Clinical Evidence Synopsis
January 20, 2015

An Overview of Treatments for Endometriosis

Author Affiliations
  • 1Liggins Institute, University of Auckland, New Zealand
  • 2Department of Obstetrics and Gynaecology, University of Auckland, New Zealand

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JAMA. 2015;313(3):296-297. doi:10.1001/jama.2014.17119

Clinical Question  What treatments are associated with improved outcomes for women with endometriosis?

Bottom Line  The levonorgestrel-releasing intrauterine system (LNG-IUD), gonadotropin-releasing hormone analogues (GnRHa; nafarelin, leuprolide, buserelin, goserelin, triptorelin), laparoscopic ablation, and excision are associated with relief of pain due to endometriosis. Gonadotropin-releasing hormone analogues and laparoscopic ablation or excision are associated with increased clinical pregnancy rates in women with endometriosis. Gonadotropin-releasing hormone analogues, danazol, and depot progestagens are associated with a higher incidence of adverse events.