January 27, 2015

Protocolized Sedation in Critically Ill Children

Author Affiliations
  • 1Department of Medicine and Interdepartmental Division of Critical Care, Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada

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JAMA. 2015;313(4):363-364. doi:10.1001/jama.2015.1

Light sedation1 or no sedation2 has become the therapeutic goal in critically ill adults. Large randomized trials35 and systematic reviews6,7 have demonstrated that this goal is feasible, safe, and beneficial. The benefits include shorter durations of mechanical ventilation and stay in the intensive care unit (ICU).24 However, prospective data supporting the benefits of minimizing sedation in children are lacking, with only 1 randomized trial of 102 children showing shorter durations of mechanical ventilation and ICU stay with daily interruption of midazolam infusions compared with no interruption.8

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