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October 17, 2007

Validity of Reported Genetic Risk Factors for Acute Coronary Syndrome

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2007;298(15):1757-1759. doi:10.1001/jama.298.15.1757-b

To the Editor: In their study of genetic risk factors for ACS, Dr Morgan and colleagues1 reported negative results for the association between 84 genetic variants in 70 candidate genes for ACS in a case-control study (811 cases and 650 controls) restricted to white patients in the United States. Small effect sizes are expected for any candidate genetic variant involved in complex diseases such as ACS. Case-control studies are prone to numerous biases, which should be carefully considered particularly when small effect sizes are analyzed.

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