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Medical News and Perspectives
October 17, 2007

Comprehensive “Proteomic Profile” of Amniotic Fluid May Aid Prenatal Diagnosis

JAMA. 2007;298(15):1751. doi:10.1001/jama.298.15.1751

Hoping to improve prenatal diagnostic testing by identifying better markers of fetal abnormalities, scientists have generated the most complete list so far of proteins present in human amniotic fluid (Cho CK et al. Mol Cell Proteomics. 2007;6[8]:1406-1415).

“There's a great need for better markers for screening for Down syndrome and other fetal abnormalities,” said principal investigator Eleftherios P. Diamandis, MD, PhD, of the Mount Sinai Hospital and the University of Toronto, in Ontario. Many expectant mothers currently receive false-positive or false-negative test results, he noted.

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