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October 24/31, 2007

Cocoa Intake and Blood Pressure—Reply

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2007;298(16):1862-1864. doi:10.1001/jama.298.16.1863

In Reply: Drs Tsikas and Rossi question the validity of the S-nitrosoglutathione assay and the clinical relevance of S-nitrosoglutathione for the blood pressure reduction described in our article. Our study reported only data from methods that have been validated according to established medical, analytical, or regulatory guidelines. To facilitate assessment of data quality for the methods used to measure main outcomes—including the S-nitrosoglutathione concentrations—essential validation parameters were presented. Requiring preceding publication of the complete validation process before allowing publication of clinical data would hamper clinically relevant “real-world” research without improving quality and clarity of the studies.

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