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November 7, 2007

Nonfasting Triglycerides and Cardiovascular Risk—Reply

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2007;298(17):2004-2006. doi:10.1001/jama.298.17.2005-b

In Reply: I concur with Dr Tsarpalis that the use of a formal oral triglyceride tolerance test (OTTT) is likely to be the best method for defining postprandial hypertriglyceridemia and to standardize the metabolic response to fat loading. In 1950, Moreton1 suggested interrelationships between chylomicronemia, fat tolerance, and atherosclerosis, and proposed that an OTTT analogous to the glucose tolerance test be used for vascular risk detection.

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