Letters Section Editor: Robert M. Golub, MD, Senior Editor.
To the Editor: In their study of limited family structure and breast cancer risk, Dr Weitzel and colleagues1 showed that women with early onset breast cancer and without a relevant family history may be at higher risk of carrying a BRCA mutation than is generally understood. However, we believe that the authors exaggerate the inadequacy of the BRCAPRO predictive model for women with limited family structure and that their proposed correction is subject to biases that make it unlikely to be validated with future data.
Iversen ES, Katki HA, Chen S, Berry DA, Parmigiani G. Limited Family Structure and Breast Cancer Risk. JAMA. 2007;298(17):2007-2008. doi:10.1001/jama.298.17.2007-a