Letters Section Editor: Robert M. Golub, MD, Senior Editor.
To the Editor: In the Women's Healthy Eating and Living (WHEL) randomized trial, Dr Pierce and colleagues1 evaluated the effect of increased dietary fruits and vegetables on breast cancer recurrence. We agree with the authors that the differences they report in between-group fat intake for participants in this trial may not have been sufficient to adequately test the dietary fat hypothesis that was raised by the interim results of the Women's Intervention Study (WINS).2
Chlebowski RT, Blackburn GL. Diet and Breast Cancer Recurrence. JAMA. 2007;298(18):2135-2136. doi:10.1001/jama.298.18.2135-a