[Skip to Content]
[Skip to Content Landing]
Citations 0
November 21, 2007

High-Density Lipoprotein and Dietary Fatty Acids—Reply

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2007;298(19):2263-2264. doi:10.1001/jama.298.19.2264

In Reply: Dr Kim distinguishes the effects of saturated fatty acids and trans-fatty acids on lipoproteins. However, reports of the effect of trans-fatty acids on HDL-C have been variable, with a large meta-analysis finding a statistically nonsignificant effect on HDL-C.1 In addition to increasing levels of LDL-C, trans-fatty acids promote vascular inflammation and endothelial dysfunction and reduce paraoxonase activity.2 These lipid and biochemical effects act synergistically to increase cardiovascular disease risk.2

First Page Preview View Large
First page PDF preview
First page PDF preview