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November 21, 2007

High-Density Lipoprotein and Dietary Fatty Acids—Reply

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2007;298(19):2263-2264. doi:10.1001/jama.298.19.2264

In Reply: Dr Kim distinguishes the effects of saturated fatty acids and trans-fatty acids on lipoproteins. However, reports of the effect of trans-fatty acids on HDL-C have been variable, with a large meta-analysis finding a statistically nonsignificant effect on HDL-C.1 In addition to increasing levels of LDL-C, trans-fatty acids promote vascular inflammation and endothelial dysfunction and reduce paraoxonase activity.2 These lipid and biochemical effects act synergistically to increase cardiovascular disease risk.2

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