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Medical News and Perspectives
November 28, 2007

Scientists Study “Senescence” in Cancer

JAMA. 2007;298(20):2357-2358. doi:10.1001/jama.298.20.2357

Madrid, Spain—Malignant cancers are adept at disrupting the body's efforts to maintain order and normalcy, but research is finding that it may be possible to reinstate the defenses that tumor cells overcome. Mechanisms that slow or inhibit the progression of cancer include apoptosis (programmed cell death) and oncogene-induced senescence, a nondividing state that occurs in response to the expression of cancer-causing genes. Disrupting these processes is often necessary for rogue cancer cells to thrive, and scientists hope that keeping them in place will have therapeutic potential.

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