Smoking before pregnancy or while breastfeeding may substantially decrease the fertility of female offspring, according to mouse studies conducted at the University of Toronto in Ontario, Canada (Jurisicova A et al. J Clin Oncol. doi: 10.1172/JCI28493 [published online ahead of print on November 21, 2007]).
Investigators discovered that female mice injected under the skin with polycyclic aromatic hydrocarbons—environmental toxins found in cigarette smoke—before pregnancy or while lactating gave birth to female offspring with ovaries that had reduced numbers of egg-containing follicles.
Hampton T. Smoking and Pregnancy. JAMA. 2007;298(21):2474. doi:10.1001/jama.298.21.2474-a