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December 19, 2007

Treatment of ANCA-Associated Vasculitis

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2007;298(23):2739-2740. doi:10.1001/jama.298.23.2739-b

To the Editor: Dr Bosch and colleagues1 considered the treatment of ANCA-associated vasculitis, discussing the relationship of its pathophysiology to current immunotherapy. The authors point out that although ANCA may be important in orchestrating neutrophil-mediated damage to the vascular endothelium, ANCA production is a T-cell driven process and novel forms of immunotherapy target this population of lymphocytes.

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