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Medical News and Perspectives
December 26, 2007

Vaccine Takes Aim at Hypertension

JAMA. 2007;298(24):2854-2855. doi:10.1001/jama.298.24.2854

Orlando, Fla—Some patients with hypertension have inadequate control of blood pressure because they are not consistently adherent in taking their medications. But help may be on the way in the form of a vaccine that lowers blood pressure by controlling angiotensin II, suggest findings from a small safety study presented at the Scientific Sessions of the American Heart Association in November.

The study of 72 patients with mild-to-moderate hypertension, presented by Jürg Nussberger, MD, professor of medicine at the University Hospital of the Canton of Vaud, Lausanne, Switzerland, found that at 14 weeks, those injected with CYT006-AngQb (at 0, 4, and 12 weeks) had a daytime systolic blood pressure that was 5.6 mm Hg lower and a diastolic blood pressure 2.8 mm Hg lower than those of patients who received placebo.

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