Riluzole, a drug that decreases glutamate release and increases glutamate uptake by astrocytes protects rats against some of the alterations in the brain that are linked to age-related memory loss, researchers report (Pereira AC et al. Proc Natl Acad Sci U S A. doi:10.1073/pnas.1421285111 [published online December 15, 2014]). The findings, from collaborators at the Rockefeller University and the Icahn School of Medicine at Mount Sinai in New York, suggest that novel glutamate modulators warrant further investigation as potentially promising agents to treat or even prevent cognitive decline.
Hampton T. Glutamate Control May Help Combat Age-Related Memory Loss. JAMA. 2015;313(5):455. doi:10.1001/jama.2015.45