In Reply We are aware of the large MOSAR-ICU quasi-experimental trial but disagree that it evaluated the addition of contact precautions to standard precautions. To our reading, the MOSAR study had 2 main phases: (1) comparing enhanced hand hygiene and chlorhexidine bathing with a baseline period and (2) comparing rapid vs conventional screening and isolation of patients with multidrug-resistant organisms, including MRSA and VRE.1 Dr Derde and colleagues imply that their trial compared standard precautions plus chlorhexidine bathing without contact precautions vs active surveillance for MRSA or VRE with contact precautions for those positive for MRSA or VRE.
Morgan DJ, Kaye KS, Diekema DJ. Contact Precautions for Patients With Multidrug-Resistant Pathogens—Reply. JAMA. 2015;313(6):630. doi:10.1001/jama.2014.17448