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July 12, 2006

Antidepressant Treatment and Relapse of Depression During Pregnancy

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2006;296(2):165-167. doi:10.1001/jama.296.2.165-b

To the Editor: The study by Dr Cohen and colleagues1 reported that a high proportion of women who discontinued antidepressant treatment during pregnancy relapsed into major depression. One of the strategies evaluated was the discontinuation of the antidepressant during the first trimester and subsequent reintroduction. The authors concluded that interrupted therapy did not prevent depressive relapse as effectively as maintaining the antidepressant throughout pregnancy.

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