Letters Section Editor: Robert M. Golub, MD, Senior Editor.
To the Editor: Dr Ding and colleagues1 concluded that there are sex-specific etiologies of type 2 diabetes because diabetes mellitus is associated with relatively elevated testosterone levels in women while the reverse holds true for men. An alternate explanation is that visceral adiposity could be a primary factor that contributes to the development of insulin resistance, altered sex steroid and sex hormone–binding globulin (SHBG) production, and diabetes in both sexes.
Bondy CA. Endogenous Sex Hormones and Type 2 Diabetes Risk. JAMA. 2006;296(2):168-170. doi:10.1001/jama.296.2.169-a