Author Affiliations: Departments of Epidemiology and Population Health (Dr Lipton) and Neurology (Drs Lipton and Bigal) Albert Einstein College of Medicine, and the Montefiore Headache Center (Drs Lipton and Bigal), Bronx, NY.
The association between migraine and ischemic vascular events has been debated for many years.1,2 Migraine with aura is now well established as a risk factor for ischemic stroke, particularly among women.3 The relationship of migraine and ischemic cardiac disease has been less clear. Several reports have demonstrated an association between migraine, particularly migraine with aura, and angina,4 although convincing evidence linking migraine to ominous cardiovascular outcomes such as myocardial infarction or coronary revascularization has not been available.
Lipton RB, Bigal ME. Migraine and Cardiovascular Disease. JAMA. 2006;296(3):332-333. doi:10.1001/jama.296.3.332