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Comment & Response
February 17, 2015

Fecal Microbiota Transplantation for Clostridium difficile Infection

Author Affiliations
  • 1Gastroenterology Department, Queen Elizabeth University Hospital Birmingham, Birmingham, England

Copyright 2015 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA. 2015;313(7):725-726. doi:10.1001/jama.2014.18617

To the Editor: Since the first description of successful fecal microbiota transplantation (FMT) via stool enemas for severe Clostridium difficile infection (CDI) in 1958,1 FMT has consistently achieved treatment success rates of approximately 90%.2 In previous work, Youngster et al3 demonstrated that it is possible to freeze stool prior to FMT, thus greatly facilitating the process. In the most recent study, Dr Youngster and colleagues4 have taken steps to transform FMT from an invasive, nonacute procedure to a potentially safe, instantly available bedside therapy for life-threatening CDI.

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