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A physician of unusual enterprise and intelligence, aged 35, an athlete weighing over 200 pounds, contracted whooping cough in May, 1903, and during convalescence from this disease began to suffer for the first time with bronchial asthma. During the summer nasal polypi were removed from the region of the middle turbinate, with much aggravation of the asthma. During the next year he was treated prominent physicians in two of the largest American cities and in Liverpool and London, more polypi being removed in the latter city. The asthma became progressively worse so that the patient came to Denver a complete invalid in October, 1904. He had at this time no free interval of over an hour, and slept in the upright posture.
This showed pronounced general asthmatic wheezing. There was marked dulness over the upper sternal region and the voice and respiratory sounds on the right were decreased
HALL JN. PROLONGED USE OF EPINEPHRIN IN ASTHMA. JAMA. 1910;55(2):128. doi:10.1001/jama.1910.04330020032016