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Comment & Response
February 24, 2015

Assessing the Benefit of Vascular Closure Devices After Femoral Artery Puncture

Author Affiliations
  • 1Department of Radiology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
JAMA. 2015;313(8):855. doi:10.1001/jama.2015.421

To the Editor Arterial closure devices have demonstrated benefits with regard to a decrease in complications and recovery time in the setting of therapeutic arterial procedures.1 A meta-analysis left a question regarding increased complication risk vs the rapid, reliable, inexpensive, and safe alternative of manual compression.2 The Instrumental Sealing of Arterial Puncture Site–CLOSURE Device vs Manual Compression (ISAR-CLOSURE) randomized clinical trial3 was an adequately powered study that provides assurance that the studied arterial closure devices were noninferior to manual compression with regard to efficacy and complications.

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