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December 17, 1910


JAMA. 1910;55(25):2158-2161. doi:10.1001/jama.1910.04330250054017

RECENT STUDIES ON TYPHUS FEVER  It will be recalled that Nicolle of Tunis, in Africa, recently succeeded in transmitting typhus fever to the macacus monkey, and that Anderson and Goldberger, working independently with the disease as it is found in Mexico City, were able to infect monkeys with blood taken from typhus patients. These results were further confirmed by the investigations of Ricketts and Wilder. Recently Gaviño and Girard1 report the transmission of typhus to monkeys of an inferior species, namely, the Ateles vellerosus, indigenous to Mexico, by subcutaneous injections of blood from typhus patients. The animals, after an incubation period of eleven to fourteen days, succumb to prostration and a high fever. An exanthematic eruption, such as occurs almost constantly in man, is absent, but the thermal elevation and other symptoms are regarded as sufficiently characteristic to permit the diagnosis of typhus. Immunity is conferred by a single

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