Early last year I presented an article1 in The Journal, giving the general negative results obtained in the treatment of general paresis with salvarsan by the subcutaneous method of administration. The results were so unsatisfactory, in many cases the salvarsan failing to be absorbed, and the method of administration being so painful, that we discontinued its use and have since used the intravenous method.
The following cases were selected with the idea of treating patients in good physical health and showing the fewest possible symptoms, mental and physical, of the ravages of this disease. As is known, patients received in a state institution have run the gauntlet of physicians and quacks and are finally taken there, as to a court of last appeal, the result being that they are generally far enough advanced in the disease to prevent many mistakes being made in diagnosis.
TROWBRIDGE EH. SALVARSAN IN GENERAL PARESIS. JAMA. 1913;60(6):429-431. doi:10.1001/jama.1913.04340060021009