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The use of serum in epidemic meningitis has so lessened the mortality of this dread disease that we are now able to classify it along with antidiphtheritic serum, but the mortality is still too high. This may be due in some cases to delayed administration, in others to the severe or fulminating character of the cases, and in still others to the presence of thick or purulent fluid which prevents the serum from permeating to all of the recesses of the tract. My object is not to go into details, but to mention a few points which may be of aid in the treatment of this condition.
According to Flexner, the serum produces its beneficial effects by acting directly on the meningococci, the multiplication of which it inhibits. The damage which is thus inflicted leads to dissolution of the cocci, which are made more susceptible to ingestion by the phagocytes.
Hirsch DI. IRRIGATION OF THE SPINAL CANAL AS A PRELIMINARY TO THE INTRODUCTION OF FLEXNER'S ANTIMENINGITIC SERUM. JAMA. 1913;60(11):828. doi:10.1001/jama.1913.04340110034016