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April 26, 1913


Author Affiliations


JAMA. 1913;60(17):1289-1290. doi:10.1001/jama.1913.04340170017009

With the desire to establish the value of prophylactic vaccination against epidemic cerebrospinal meningitis, experiments were undertaken by Dr. Abraham Sophian and myself during the month of April, 1912. This work was done on ten medical students who were in good health and volunteered for the work. These men were vaccinated with three doses at seven-day intervals. To half of them doses of 500 million, 1,000 million and 1,000 million were given. The other five received doses twice as large. Examinations of their blood were undertaken at once and showed an early development of agglutinins and immune bodies which increased after the second and third injections and, with considerable uniformity, reached a high degree. This work was reported in The Journal.1

The value of prophylactic vaccination must depend, not only on the agglutinins and immune bodies developed, but also on their persistence. If it can be shown that a

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