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After more than twenty years of experimentation and clinical experience, the time has arrived, when a sufficient amount of truth regarding the tuberculin reaction as a diagnostic and curative agent has crystallized to make it worth while in the opinion of the authors of this work to put it into systematic and permanent form. The work is the result of a large personal experience, which permits the production of a book of special practical value. Since correct views regarding the important clinical phenomena involved in the use of tuberculin can only be based on a clear understanding of the nature of tuberculin and the limitations of its activity, a considerable amount of theoretical matter has necessarily been introduced. The limitations of tuberculin as a diagnostic agent are clearly stated, and its use only as a subsidiary method is strongly urged. The impossibility of distinguishing by its means in ordinary cases
Tuberculin in Diagnosis and Treatment.. JAMA. 1913;60(19):1489. doi:10.1001/jama.1913.04340190083032