Pompholyx was first described, as a form of dyshydrosis, by Tilbury Fox,1 who was of the opinion that the condition was characterized essentially by "the retention in the follicles of the skin of sweat, rapidly and freely excreted," and believed that the affection bore the same relation to the sweat follicles that acne vulgaris does to the sebaceous glands. Hutchinson2 who independently recognized and described the disease at about the same time, was opposed to this view, and, basing his argument on the symmetry and the spontaneous appearance and disappearance of the clinical manifestations, and on the fact that the condition was seen most frequently in persons whose vitality had been lowered by worry, overwork and similar agencies, concluded that it was an acute, inflammatory disease of the rete, neurotic in origin. He3 suggested for it the name "cheiropompholyx."
SUTTON RL. THE HISTOPATHOLOGY OF POMPHOLYX. JAMA. 1913;61(4):240-244. doi:10.1001/jama.1913.04350040006003