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A soldier, aged 24, weighing 145 pounds, presented himself with a solitary ulcer of five days' duration, the exudate from which on examination by the India ink method revealed the Spirochaeta pallida. Neodiarsenol in a dose of 0.45 gm. in 10 c.c. of sterile distilled water was given intravenously in my office. It was noted that the powder was extremely slow in dissolving and that the resulting solution was mahogany colored.
Immediately after the administration, the patient complained of a choking sensation and intense pricking pains in the soles of the feet and palms of the hands which he described as being similar to the sensation of being beaten with a stiff bristle brush.
While I was searching for some epinephrin, the patient reeled out of the chair in which he had been sitting and fell prone on the floor, unconscious. He remained in this state for about two minutes,
Ross TW. SERIOUS RESULTS FOLLOWING THE ADMINISTRATION OF NEODIARSENOL. JAMA. 1918;70(3):155. doi:10.1001/jama.1918.26010030002009d