It is generally accepted that less exogenous uric acid is eliminated by persons subject to gout than by normal persons. It is still disputed whether or not this lessened excretion of exogenous uric acid can be used for diagnosis.
Vogt, Reach, Soetbeer, Pollak, Mallory, Weinberger and Yavein have found that in gout the excretion of exogenous purins is diminished and delayed. This is not always the case according to Magnus-Levy, Weintraud, Rommel and Pratt.
In a recent article, McClure and Pratt1 present tables showing a summary of all the previous observations on the exogenous uric acid excretions of normal persons, of patients with chronic arthritis, and of gouty patients. They have studied the uric acid excretion in two cases of gout after the feeding of sweetbreads.
They believe that the retention of uric acid is a symptom of questionable importance in the diagnosis of gout.
In the present
ROSENBLOOM J. EXCRETION OF INGESTED PURINS IN CHRONIC GOUTA STUDY OF TWO CASES. JAMA. 1918;70(5):285–286. doi:10.1001/jama.1918.02600050007003