[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Views 343
Citations 0
Lab Reports
March 3, 2015

Analysis Provides Map of Protein Expression in Human Tissues

JAMA. 2015;313(9):885. doi:10.1001/jama.2015.0691

Investigators have analyzed the Human Protein Atlas to provide detailed information on the proteins expressed in the body—for example, identifying those proteins linked to cancer, estimating the number that are present in the bloodstream, and determining those that are targets for approved drugs on the market (Uhlén M et al. Science. doi:10.1126/science.1260419 [published online January 23, 2015]).

By applying RNA expression analyses and antibody-based identification techniques across 32 human tissues and organs, a team led by Swedish researchers estimated that 44% of proteins are active in all tissues, many with “housekeeping” functions related to cell growth and metabolism. The testes have the most tissue-enriched proteins, while the second largest number of enriched proteins is the brain.

First Page Preview View Large
First page PDF preview
First page PDF preview