To the Editor The systematic review by Dr Clement and colleagues1 about the treatment of syphilis lacked a critical approach to the problem and provided a tenuous conclusion that “the mainstay of syphilis treatment is parenteral penicillin G despite the relatively modest clinical trial data that support its use.” In addition, the authors did not consider why neurosyphilis may be repeatedly detected in immunocompetent patients despite conventional therapy for early syphilis.
Drago F, Ciccarese G, Rebora A. Treatment of Late-Stage Syphilis. JAMA. 2015;313(9):969. doi:10.1001/jama.2015.0672