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Comment & Response
March 3, 2015

Treatment of Late-Stage Syphilis—Reply

Author Affiliations
  • 1Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina
  • 2Division of Infectious Diseases, University of California, San Diego
JAMA. 2015;313(9):969-970. doi:10.1001/jama.2015.0675

In Reply Drs van Brussel and Landman highlight the potential role of probenecid in treating neurosyphilis and note the mechanism by which it enhances penicillin concentrations within the central nervous system. The cited study by Morrison et al1 showed that the combination of amoxicillin with probenecid cured syphilitic orchitis in rabbits. However, the human group in this study provided evidence only that adequate treponemicidal CSF concentrations were achieved with combined amoxicillin-probenecid.

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