[Skip to Content]
[Skip to Content Landing]
March 23, 1918


Author Affiliations


From the Laboratory of Physiological Chemistry, University of Pittsburgh School of Medicine.

JAMA. 1918;70(12):846-847. doi:10.1001/jama.1918.26010120004012a

At the suggestion of the National Research Council, extensive investigations on shock have been undertaken. Numerous theories have been offered as to the cause of the condition termed "shock." One attributes the condition to acidosis, and sodium bicarbonate has been suggested in the treatment.

In connection with observations on shock carried on in this laboratory, a preliminary report of which has been published,1 studies on the acidosis factor were undertaken. The results of these observations form the context of this report.

METHODS OF EXPERIMENTATION  The method of producing shock and judging of the condition has been described in a previous report.1 Essentially, they comprise prolonged strong rhythmic stimulation of the afferent nerves of dogs, under ether anesthesia. Under such circumstances the time required to establish the condition varied greatly in different animals. When necessary, the onset of the condition was hastened by other means, such as exposure and

First Page Preview View Large
First page PDF preview
First page PDF preview