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Article
April 13, 1918

PREVENTION OF BLOOD CLOTTING BY DAKIN'S SODIUM HYPOCHLORITE SOLUTION

Author Affiliations

New York. Department of Physiology and Pharmacology, Rockefeller Institute for Medical Research.

JAMA. 1918;70(15):1115-1116. doi:10.1001/jama.1918.02600150069021

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Abstract

To the Editor:  —We wish to record here very briefly a few facts with regard to the action of Dakin's solution on clotting. The solution used was obtained from the War Demonstration Hospital (Rockefeller Institute) freshly prepared every morning. Dog's, cat's and rabbit's blood flowed from an artery directly into Dakin's solution, one part of Dakin's solution to every five parts of blood. Such blood remains unclotted for ten or more days. For older solutions larger proportions must be used. The addition of a sufficient quantity of a calcium salt does not produce clotting. Neither does the blood become clotted by the addition of a foreign body, nor does fibrin form by whipping. The solution in this proportion produces a gradual laking of the red cells. When blood is drawn into an oxalate and centrifugalized, a clear plasma is obtained; when Dakin's solution is added to such plasma and the

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