May 11, 1918


JAMA. 1918;70(19):1375-1376. doi:10.1001/jama.1918.02600190031012

If some semblance of an orderly and logical conception of the possible nature of the so-called intestinal intoxication, or diarrhea with toxic symptoms, in infants is beginning to arise out of the chaos of past uncertainties, we owe it largely to the more exact methods of recent clinical study. Phenomena suggesting toxicity and occurring in association with profound nutritional disorder in infants have long been recognized; but mere empiric observations, and routine measurements of pulse and temperature, casual inspection of stools, and manipulations of diet have not promoted any noteworthy advance in the understanding of a clinical entity. It is due to the persistent and often little appreciated efforts of a small group of investigators in the domain of pediatrics, notably in American laboratories, where successful methods have been so skilfully developed in the past few years, that substantial progress is being recorded.

If this statement needs to be justified,

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