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To the Editor:
—Referring to the article of Dr. Noguchi (The Journal, April 20, 1918, p. 1157) and his supplementary note (April 27, p. 1252) on the use of sodium acetate in preserving guinea-pig complement for the serum diagnosis of syphilis, I should like to add that while sodium acetate does work very well with many guinea-pig serums, it is not entirely satisfactory with some specimens, owing to a certain amount of precipitation that occurs occasionally. The sharp reactions and rapid hemolysis that tend to take place with complement preserved with the acetate has in my experience during the last six months indicated that in the weaker positive reactions they were more likely to become negative, thereby giving one a misleading result. This so far is the only criticism that I could make regarding the use of sodium acetate for the purpose. I might say that with the ice-box method
Hindman SS. SERUM DIAGNOSIS OF SYPHILIS. JAMA. 1918;70(21):1561-1562. doi:10.1001/jama.1918.02600210051024